Search results for "Fraction of inspired oxygen"

showing 9 items of 9 documents

Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review

2021

Abstract Background The mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechanics are currently scarce and the optimal setting of MV remains to be defined. This scoping review aims to provide an overview of available data about respiratory mechanics, gas exchange and MV settings in patients admitted to intensive care units (ICUs) for COVID-19-associated acute respiratory failure, and to identify knowledge gaps. Main text PubMed, EMBASE, and MEDLINE databases were searched from inception to October 30, 2020 for studies providing at least one v…

ARDSmedicine.medical_specialtyCritical Illnessmedicine.medical_treatmentReviewRespiratory physiologyCritical Care and Intensive Care MedicineHypoxemia03 medical and health sciencesMechanical ventilation0302 clinical medicineIntensive careFraction of inspired oxygenmedicineHumansIntensive care unitMechanical ventilation.Positive end-expiratory pressureMechanical ventilationRespiratory Distress SyndromeIntensive care unitsCoronavirus disease 2019Acute respiratory distress syndromebusiness.industrylcsh:Medical emergencies. Critical care. Intensive care. First aidCOVID-19030208 emergency & critical care medicinelcsh:RC86-88.9medicine.diseaseRespiration Artificial030228 respiratory systemEmergency medicineRespiratory Mechanicsmedicine.symptombusinessCohort studyCritical Care
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Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study

2020

Abstract Background Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence o…

ARDSmedicine.medical_treatment030204 cardiovascular system & hematologyCritical Care and Intensive Care MedicineHyperoxemiaHypoxemialaw.inventionHypoxemia0302 clinical medicinelawFraction of inspired oxygenOxygen therapyPrevalenceMedicineHypoxiaAcute respiratory distress syndrome; Hyperoxemia; Hyperoxia; Hypoxemia; Hypoxia; Invasive mechanical ventilation; Mortality; Oxygen therapy;Respiratory Distress SyndromeHyperbaric OxygenationAcute respiratory distress syndromeRespirationlcsh:Medical emergencies. Critical care. Intensive care. First aidHyperoxemiaIntensive care unitIntensive Care UnitsAnesthesiaArtificialmedicine.symptomHumanArtificial ventilationAcute respiratory distress syndrome; Hyperoxemia; Hyperoxia; Hypoxemia; Hypoxia; Invasive mechanical ventilation; Mortality; Oxygen therapyIntensive Care UnitHyperoxiaNO03 medical and health sciencesIntensive careSettore MED/41 - ANESTESIOLOGIAHumansInvasive mechanical ventilationMortalitybusiness.industryResearchRespiratory Distress Syndrome Adultlcsh:RC86-88.9medicine.diseaseOxygen therapyRespiration Artificialrespiratory tract diseasesOxygenlnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]030228 respiratory systembusiness
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Supplemental Perioperative Oxygen and the Risk of Surgical Wound Infection: A Randomized Controlled Trial

2006

ABSTRACT Three hundred patients were enrolled in a double-blind, randomized, controlled study designed to investigate the ability of supplemental perioperative oxygen to reduce wound infection. Participants were age 18 to 80 years, had no coexisting serious medical conditions, and were scheduled to undergo elective colorectal surgery at one of 14 participating hospitals in Spain. No patients undergoing minor or laparoscopic surgery were included. Anesthesia and antibiotic prophylaxis were standardized for the study. Patients were randomized by computer-generated codes to receive an oxygen/air mixture of 30% or 80% fraction of inspired oxygen (F102) intraoperatively and postoperatively for 6…

Laparoscopic surgerymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentObstetrics and GynecologySurgical woundGeneral MedicinePerioperativeColorectal surgerySurgerylaw.inventionRandomized controlled triallawFraction of inspired oxygenRelative riskmedicineAntibiotic prophylaxisbusinessObstetrical & Gynecological Survey
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LACTATE, NOT GLUCOSE, UP-REGULATES MITOCHONDRIAL OXYGEN CONSUMPTION BOTHIN SHAM AND LATERAL FLUID PERCUSSED RAT BRAINS

2006

OBJECTIVE: Failure of energy metabolism after traumatic brain injury may be a major factor limiting outcome. Although glucose is the primary metabolic substrate in the healthy brain, the well documented surge in tissue lactate after traumatic brain injury suggests that lactate may provide an energy need that cannot be met by glucose. We hypothesized, therefore, that administration of lactate or the combination of lactate and supraphysiological oxygen may improve mitochondrial oxidative respiration in the brain after rat fluid percussion injury. We measured oxygen consumption (VO2) to determine what effects glucose, lactate, oxygen, and the combination of lactate and oxygen have on mitochond…

Malemedicine.medical_specialtyTraumatic brain injuryCell RespirationOxidative phosphorylationMitochondrionRats Sprague-Dawleychemistry.chemical_compoundOxygen ConsumptionFraction of inspired oxygenInternal medicineRespirationmedicineAnimalsLactic AcidDose-Response Relationship Drugbusiness.industryBrainmedicine.diseaseMitochondriaRatsUp-RegulationCartesian diverLactic acidOxygenDose–response relationshipGlucoseEndocrinologychemistryBrain InjuriesAnesthesiaSurgeryNeurology (clinical)businessNeurosurgery
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Closed-Loop Automatic Oxygen Control (CLAC) in Preterm Infants: A Randomized Controlled Trial

2014

BACKGROUND AND OBJECTIVE: In preterm infants receiving supplemental oxygen, routine manual control (RMC) of the fraction of inspired oxygen (FIO2) is often difficult and time consuming. We developed a system for closed-loop automatic control (CLAC) of the FIO2 and demonstrated its short-term safety and efficacy in a single-center study. The objective of this study was to test the hypothesis that this system is more effective than RMC alone in maintaining arterial oxygen saturation within target levels when evaluated over 24 hours under routine conditions and with different target levels. METHODS: We performed a multicenter, randomized controlled, crossover clinical trial in 34 preterm infa…

Malemedicine.medical_treatmentlaw.inventionRandomized controlled triallawOxygen therapyFraction of inspired oxygenHumansMedicineSingle-Blind MethodContinuous positive airway pressureHyperoxiaMechanical ventilationContinuous Positive Airway Pressurebusiness.industryInfant NewbornRespiration ArtificialOxygenOxygen Saturation MeasurementAnesthesiaPediatrics Perinatology and Child HealthBreathingFemalemedicine.symptombusinessInfant PrematurePediatrics
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Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

2020

Background There is no proven specific pharmacological treatment for patients with the acute respiratory distress syndrome (ARDS). The efficacy of corticosteroids in ARDS remains controversial. We aimed to assess the effects of dexamethasone in ARDS, which might change pulmonary and systemic inflammation and result in a decrease in duration of mechanical ventilation and mortality. Methods We did a multicentre, randomised controlled trial in a network of 17 intensive care units (ICUs) in teaching hospitals across Spain in patients with established moderate-to-severe ARDS (defined by a ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen of 200 mm Hg or less assesse…

Pulmonary and Respiratory MedicineAdultMaleARDSmedicine.medical_treatmentSeverity of Illness IndexDexamethasonelaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawFraction of inspired oxygenIntensive careSeverity of illnessmedicineData monitoring committeeHumans030212 general & internal medicineGlucocorticoidsDexamethasoneAgedMechanical ventilationRespiratory Distress Syndromebusiness.industryMiddle Agedmedicine.diseaseRespiration ArtificialIntensive Care UnitsTreatment Outcome030228 respiratory systemAnesthesiaAdministration IntravenousFemalebusinessmedicine.drug
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Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distr…

2019

The effect of personalised mechanical ventilation on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remains uncertain and needs to be evaluated. We aimed to test whether a mechanical ventilation strategy that was personalised to individual patients' lung morphology would improve the survival of patients with ARDS when compared with standard of care.We designed a multicentre, single-blind, stratified, parallel-group, randomised controlled trial enrolling patients with moderate-to-severe ARDS in 20 university or non-university intensive care units in France. Patients older than 18 years with early ARDS for less than 12 h were randomly assigned (1:1) to either th…

Pulmonary and Respiratory MedicineMalemedicine.medical_specialtyARDSmedicine.medical_treatment[SDV]Life Sciences [q-bio]law.inventionPositive-Pressure Respiration03 medical and health sciences0302 clinical medicineRandomized controlled triallawInternal medicineFraction of inspired oxygenIntensive caremedicineProne PositionTidal VolumeHumansSingle-Blind Method030212 general & internal medicineProspective StudiesPrecision MedicineLungPositive end-expiratory pressureTidal volumeComputingMilieux_MISCELLANEOUSProportional Hazards ModelsMechanical ventilationRespiratory Distress Syndromebusiness.industryHazard ratioMiddle Agedmedicine.diseaseRespiration Artificial3. Good health[SDV] Life Sciences [q-bio]Intensive Care UnitsEditorial CommentaryTreatment Outcome030228 respiratory systemFemaleFrancebusiness
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Lung Injury Is a Predictor of Cerebral Hypoxia and Mortality in Traumatic Brain Injury

2020

Background: A major contributor to unfavorable outcome after traumatic brain injury (TBI) is secondary brain injury. Low brain tissue oxygen tension (PbtO2) has shown to be an independent predictor of unfavorable outcome. Although PbtO2 provides clinicians with an understanding of the ischemic and non-ischemic derangements of brain physiology, its value does not take into consideration systemic oxygenation that can influence patients' outcomes. This study analyses brain and systemic oxygenation and a number of related indices in TBI patients: PbtO2, partial arterial oxygenation pressure (PaO2), PbtO2/PaO2, ratio of PbtO2 to fraction of inspired oxygen (FiO2), and PaO2/FiO2. The primary aim …

medicine.medical_specialtyTraumatic brain injuryLung injurylcsh:RC346-42903 medical and health sciences0302 clinical medicineInternal medicineFraction of inspired oxygenmedicinecerebral oxygenationCerebral perfusion pressurelung injurylcsh:Neurology. Diseases of the nervous systemIntracranial pressureOriginal Researchpartial arterial oxygen pressurebusiness.industrycerebral oxygenation; hypoxia threshold; lung injury; mortality outcome; partial arterial oxygen pressure; traumatic brain injurymortality outcometraumatic brain injuryCerebral hypoxiaNeurointensive care030208 emergency & critical care medicinehypoxia thresholdrespiratory systemmedicine.diseaseOxygen tensionrespiratory tract diseasesNeurologyCardiologyNeurology (clinical)business030217 neurology & neurosurgerycirculatory and respiratory physiologyFrontiers in Neurology
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Supplemental Perioperative Oxygen and the Risk of Surgical Wound Infection<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2005

ContextSupplemental perioperative oxygen has been variously reported to halve or double the risk of surgical wound infection.ObjectiveTo test the hypothesis that supplemental oxygen reduces infection risk in patients following colorectal surgery.Design, Setting, and PatientsA double-blind, randomized controlled trial of 300 patients aged 18 to 80 years who underwent elective colorectal surgery in 14 Spanish hospitals from March 1, 2003, to October 31, 2004. Wound infections were diagnosed by blinded investigators using Centers for Disease Control and Prevention criteria. Baseline patient characteristics, anesthetic treatment, and potential confounding factors were recorded.InterventionsPati…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentSurgical woundGeneral MedicinePerioperativeColorectal surgerySurgerylaw.inventionRandomized controlled triallawRelative riskFraction of inspired oxygenmedicineRisk factorbusinessColectomyJAMA
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